AUTHOR=Chen Zhangxin , Zhang Cong , Hong Haisen , Xu Wenbin , Sha Mo , Ding Zhenqi 

TITLE=Potential alternative drug treatment for bone giant cell tumor

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1193217

DOI=10.3389/fcell.2023.1193217

ISSN=2296-634X

ABSTRACT=Background: Bone Giant-cell tumor (BGCT) is one of the world's major diseases of a locally aggressive bone tumor. In recent years the denosumab treatment has been introduced before curettage surgery. However, the current therapeutic was not always practical given the local recurrence effects. Due to the complex nature of BGCT, This study aims to use bioinformatics to identify potential genes and drugs associated with BGCT.