AUTHOR=Singh Abhishek K. , Prasad Parash , Cancelas Jose A. 

TITLE=Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1325291

DOI=10.3389/fcell.2023.1325291

ISSN=2296-634X

ABSTRACT=Stem cell (HSC) transplantation-based treatments are in different phases of clinical development ranging from current therapies to a promise in the repair and regeneration of diseased tissues and organs. Mesenchymal stromal/stem cells (MSCs), which are fibroblast-like heterogeneous progenitors with multilineage differentiation (osteogenic, chondrogenic, and adipogenic) and selfrenewal potential and exist in bone marrow (BM), adipose, and synovium, among other tissues, represent one of most widely sources of stem cells in regenerative medicine. MSCs generated from bone marrow (BM-MSCs) exhibit a variety of traits, including the potential to drive hematopoietic stem cell fate as well as anti-inflammatory and immunosuppressive capabilities via paracrine activities and interactions with the innate and adaptive immune systems. The role of BM-MSC derived adipocytes is more controversial and may act as positive or negative regulators of benign or malignant hematopoiesis based on their anatomical location and functional crosstalk with surrounding cells in the BM microenvironment. This review highlights the most recent clinical and pre-clinical findings on how BM-MSCs interact with the surrounding hematopoietic stem cells, progenitors and immune cells and address some recent insights on the mechanisms that mediate MSC and adipocyte metabolic control through metabolic crosstalk between BM microenvironment cells as well as intercellular mitochondrial transfer in normal and malignant hematopoiesis.