AUTHOR=Su Chuanchao , Xue Yiwen , Fan Siyu , Sun Xin , Si Qian , Gu Zhen , Wang Jingfei , Deng Runzhi 

TITLE=Ferroptosis and its relationship with cancer

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 12 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1423869

DOI=10.3389/fcell.2024.1423869

ISSN=2296-634X

ABSTRACT=Marked by iron buildup and lipid peroxidation, ferroptosis is a relatively new regulatory cell death (RCD) pathway. Many diseases like cancer, myocardial ischemia-reperfusion injury (MIRI), neurological disorders and acute renal failure (AKI) are corelated with ferroptosis. The main molecular processes of ferroptosis discovered yet will be presented here, along with the approaches in which it interacts with tumour-associated signaling pathways and its uses in systemic therapy, radiation therapy, and immunotherapy managing tumors.