AUTHOR=Kuang Weihong , Xu Jialin , Xu Fenting , Huang Weizhen , Majid Muhammad , Shi Hui , Yuan Xia , Ruan Yongdui , Hu Xianjing 

TITLE=Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1513426

DOI=10.3389/fcell.2024.1513426

ISSN=2296-634X

ABSTRACT=Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG.