AUTHOR=Xie Siyi , Liu Meiling , Kong Yajie , Yang Yiming , Chen Ruixue , Wang Yuzhong , Cao Shuxing , Song Yongzhou 

TITLE=Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1549096

DOI=10.3389/fcell.2025.1549096

ISSN=2296-634X

ABSTRACT=Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors and high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, and improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos in the treatment of OA and T2DM, the potential mechanisms of MSC-Exos, and the therapeutic strategies of engineered exosomes. Although MSC-Exo therapy shows promising therapeutic potential, further research is needed to validate its safety and feasibility.