AUTHOR=Chen Xu , Zheng Liying , Zeng Xianxu , Pan Nanying 

TITLE=The potential role of miR-155 in the tumorigenesis of cervical cancer

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1572373

DOI=10.3389/fcell.2025.1572373

ISSN=2296-634X

ABSTRACT=Cervical cancer poses a major threat to the health of females and is the leading cause of mortality in females. Despite advancements in treatment, most cervical cancer patients have a poor prognosis due to late diagnosis and resistance to treatment. Investigating microRNAs introduces a new path for developing cancer prevention and treatment. miR-155, one of many microRNAs, plays an essential role in tumor development by regulating gene expression processes, such as transcription, translation, and splicing. In cervical cancer, a number of studies have been conducted to exploring the role and mechanisms of miR-155. Therefore, a comprehensive review summarizing all available findings is necessary to clarify the role of miR-155 in cervical cancer development and progression. This review presents an overview of the state-of-the-art research in miR-155 for cervical cancer, including cell apoptosis, migration, invasion, and drug resistance, and highlights its potential as a biomarker and therapeutic target for cervical cancer treatment and prognosis.