AUTHOR=Zhang Ting , Zhang Yusu , Xie Jinpeng , Lu Dandan , Wang Lihong , Zhao Shuaifei , Zhou Jing , Cheng Yang , Kou Ting , Wang Jue , Chen Ying , Xu Lei , Hu Xiangyu , Ying Yuxiu , Wang Jun , Xin Xiaoshuang , Xu Xu , Lei Siyun , Qiu Chenyu , Wu Jinhua , Lyu Qiqi , Cao Tong 

TITLE=Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1577382

DOI=10.3389/fcell.2025.1577382

ISSN=2296-634X

ABSTRACT=Ferroptosis, a non-apoptotic, iron-dependent form of regulated cell death, is closely related to the pathogenesis of neurodegenerative diseases. Stem cells and their derivatives exhibit remarkable potential in modulating ferroptosis, offering promising therapeutic intervention for neurodegenerative diseases. In this review, we systematically explore neurological aging and its association with cognitive impairment and neurodegenerative diseases, with focus on the molecular mechanisms of ferroptosis in neurodegenerative diseases and the potential therapeutic strategies of stem cell derivatives for neurological diseases.