AUTHOR=Ding Yiheng , Wei Ziqiang , Wang Chaoyun , Li Xinyue , Li Bingbing , Liu Xueting , Fu Zhijie , Mo Hongwei , Zhang Hong 

TITLE=Using deep learning to screen OCTA images for hypertension to reduce the risk of serious complications

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1581785

DOI=10.3389/fcell.2025.1581785

ISSN=2296-634X

ABSTRACT=BackgroundAs a disease with high global incidence, hypertension is known to cause systemic vasculopathy. Ophthalmic vessels are the only vascular structures that can be directly observed in vivo in a non-invasive manner. We aim to investigate the changes in ocular microvessels in hypertension using deep learning on optical coherence tomography angiography (OCTA) images.MethodsThe convolutional neural network architecture Xception and multi-Swin transformer were used to screen 422 OCTA images (252 from 136 hypertension subjects; 170 from 85 healthy subjects) for hypertension. Moreover, the separability of the OCTA images based on high-dimensional feature angles was analyzed to better understand how deep learning models distinguish such images with class activation mapping.ResultsUnder Xception, the overall average accuracy of 5-fold cross-validation was 76.05% and sensitivity was 85.52%. In contrast, the Swin transformer showed single-model (macular), single-model (optic disk), and multimodel average accuracies of 82.25%, 74.936%, and 85.06%, respectively, for predicting hypertension.ConclusionThe changes caused by hypertension on the fundus vessels can be observed more accurately and efficiently using OCTA image features through deep learning. These results are expected to assist with screening of hypertension and reducing the risk of its severe complications.Trial RegistrationChiCTR, ChiCTR2000041330. Registered 23 December 2020, https://www.chictr.org.cn/ChiCTR2000041330.