AUTHOR=Zhang Lin , Zhao Yaqi , Shi Xiaolu , Wu Fan , Shen Yi 

TITLE=Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1590009

DOI=10.3389/fcell.2025.1590009

ISSN=2296-634X

ABSTRACT=As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.