AUTHOR=Yin Meng-ting , Guo Liang 

TITLE=Exercise in atherosclerosis: its beneficial effects and underlying mechanism

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1598794

DOI=10.3389/fcell.2025.1598794

ISSN=2296-634X

ABSTRACT=Atherosclerosis represents a complex interplay of inflammatory and metabolic processes, in which oxidative stress, endothelial inflammation, the phenotypic transition of smooth muscle cells (SMCs), and the conversion of macrophages into foam cells are involved. In contrast to pharmacological interventions, exercise emerges as a viable, cost-effective, and low-risk strategy to alleviate the progression of atherosclerosis. Exercise exerts beneficial effects on atherosclerosis through modulation of diverse pathways, including exerkines, browning of adipose tissue, the renin-angiotensin system (RAS), metabolites, gut microbiota, cell death pathways, microRNAs, nervous system, and immune function. The beneficial impacts of exercise on atherosclerosis and the mechanisms behind them will be examined here. Fully understanding the effects and mechanisms of exercise in reducing atherosclerosis might open doors to developing safe and effective interventions.