AUTHOR=Yang Bo , Zheng Quan , Li Guozheng , Liao Bingnan , Lin Zhongxiao , He Hao 

TITLE=Advancing therapeutic target discovery in pulmonary diseases: evolution and application of space exploration technologies

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1657720

DOI=10.3389/fcell.2025.1657720

ISSN=2296-634X

ABSTRACT=Epigenetic alterations are associated with various pulmonary diseases. In recent years, the concept of epigenetic inheritance influenced by spatial variations has garnered increasing attention. Alterations in three-dimensional (3D) chromatin architecture have been demonstrated to play a crucial role in regulating gene expression and influencing the pathogenesis and progression of lung-related diseases. Techniques such as high-throughput chromosome conformation capture (Hi-C) have emerged as powerful tools for detecting spatial chromatin conformational changes. In this review, we summarize key targets identified through Hi-C and related methodologies in the context of pulmonary diseases and explore their potential implications for epigenetic therapies.