AUTHOR=Dunn Diana M. , Munger Joshua 

TITLE=Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.00384

DOI=10.3389/fcimb.2020.00384

ISSN=2235-2988

ABSTRACT=Calcium signaling and the AMP-activated protein kinase (AMPK) signaling network broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMP-activated protein kinase (AMPK) signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.