AUTHOR=Minakshi Rinki , Jan Arif Tasleem , Rahman Safikur , Kim Jihoe 

TITLE=A Testimony of the Surgent SARS-CoV-2 in the Immunological Panorama of the Human Host

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.575404

DOI=10.3389/fcimb.2020.575404

ISSN=2235-2988

ABSTRACT=The resurgence of SARS in the late December of 2019 due to a novel coronavirus, SARS-CoV-2, has shadowed the world with a pandemic. The physiopathology of this virus is very much in semblance with the previously known SARS-CoV and MERS-CoV. However, the unprecedented transmissibility of SARS-CoV-2 has been puzzling the scientific efforts. Though the virus stashes lots of its genetic and architectural features of SARS-CoV, a few differences acquired during its evolutionary selective pressure is helpingSARS-CoV-2 to establish infection prodigiously. Making entry into host cell through already established ACE-2 receptor concerted with the action of TMPRSS2, is considered important for the virus. During the infection cycle of SARS-CoV-2, innate immunity witnesses maximum dysregulations in its molecular network causing fatalities in aged, comorbid cases. The overt immunopathology manifested due to robust cytokine storm shows ARDS in severe cases of SARS-CoV-2. A delayed IFN activation gives appropriate time to the replicating virus for evasion of host antiviral response and cause derangement in adaptive response as well. We have compiled various aspects of SARS-CoV-2 in relation to its unique structural features and ability to modulate innate as well adaptive response in host, aiming at understanding the dynamism of infection.