AUTHOR=Loke Yean Leng , Chew Ming Tsuey , Ngeow Yun Fong , Lim Wendy Wan Dee , Peh Suat Cheng 

TITLE=Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.603086

DOI=10.3389/fcimb.2020.603086

ISSN=2235-2988

ABSTRACT=Colorectal cancer (CRC) incidence increases yearly, and it is three to four times higher in developed countries compared to the developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red, processed meats and alcohol, and low dietary fibres. There is growing evidence of the interplay between diet and gut microbiota in colon carcinogenesis. As diet factors influence CRC risk, essential diets include proteins, carbohydrates, fat and their end product are discussed together with colon carcinogenesis and the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also highlighted. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damages play roles in dysbiosis and colon carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components towards promoting colonic neoplasm together with interacting with gut microbiota. Dietary intervention and gut microbiota modulation play vital role in reducing CRC risk.