AUTHOR=Zhu Huai-Chang , Jia Xiao-Kang , Fan Yong , Xu Shao-Hua , Li Xiao-Yan , Huang Ming-Qing , Lan Meng-Liu , Xu Wen , Wu Shui-Sheng 

TITLE=Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.640225

DOI=10.3389/fcimb.2021.640225

ISSN=2235-2988

ABSTRACT=Hunting for natural compounds that can modulate the structure of the intestinal flora is a new hotspot for colitis‐associated cancer (CAC) prevention or treatment. Alisol B 23-acetate (AB23A) is a natural tetracyclic triterpenoid found in Alismatis rhizoma which is well known for dietary herb. In this study, we investigated the therapeutic potential of AB23A in mouse models of azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced CAC. AB23A treatment alleviated the body weight loss, disease activity index, colon tumor load, tissue injury, and inflammatory cytokine changes in CAC mice. AB23A treatment leads to remarkable reductions in the activation of TLR4 and NF-κB. AB23A significantly decreased the phosphorylation of p38, ERK, and JNK and up-regulated mucin-2 and the expression of tight junction proteins. The gut microbiota of AB23A-treated mice was characterized with high microbial diversity, the reduced expansion of pathogenic bacteria, such as Klebsiella, Citrobacter, and Akkermansia, and the increased growth of bacteria including Bacteroides, Lactobacillus, and Alloprevotella. These data reveal that AB23A has the potential to represent novel prebiotics that may be used to treat CAC in the future.