AUTHOR=Juanes-Velasco Pablo , Landeira-Viñuela Alicia , Acebes-Fernandez Vanessa , Hernández Ángela-Patricia , Garcia-Vaquero Marina L. , Arias-Hidalgo Carlota , Bareke Halin , Montalvillo Enrique , Gongora Rafael , Fuentes Manuel 

TITLE=Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.642583

DOI=10.3389/fcimb.2021.642583

ISSN=2235-2988

ABSTRACT=Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to infections. Individual genetic variation may help to explain different immune responses to microrganisms across a population. HLA typing can be fast and inexpensive; however, decipher peptides loaded in MHC-I and II, is requiring design and development of multiples methodological approaches and databases, which could help in the development of vaccines and identify high-risk HLA types to be prioritized for vaccination programs. Here, it is reviewed the recent developments and strategies in this field and discussed the next steps to promote translation into biomedicine.