AUTHOR=Quinti Isabella , Mortari Eva Piano , Fernandez Salinas Ane , Milito Cinzia , Carsetti Rita 

TITLE=IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.655896

DOI=10.3389/fcimb.2021.655896

ISSN=2235-2988

ABSTRACT=A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. SARS-Cov-2 IgA antibody responses greatly contributed to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency showing an increased length of SARS-CoV-2 positivity. A condition of silent Selective IgA Deficiency should be search in SARS-CoV-2 patients whose oropharyngeal swabs test positive for a long period of time.