AUTHOR=Yu Yedong , Wei Chunchun , Lyu Junhao , Wu Xiaoliang , Wang Rending , Huang Hongfeng , Wu Jianyong , Chen Jianghua , Peng Wenhan 

TITLE=Donor-Derived Human Parvovirus B19 Infection in Kidney Transplantation

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.753970

DOI=10.3389/fcimb.2021.753970

ISSN=2235-2988

ABSTRACT=Background: Donor-derived human parvovirus B19 infections are rarely reported. Thus, it’s incidence in kidney transplantation is still unknown due to lack of surveillance studies. Similarly, whether the donor needs to be routinely screened for human parvovirus B19 and whether the kidneys from those with human parvovirus B19 DNAemia could be accepted also remains unknown. 
Methods: This retrospective study aims to evaluate the donor-derived human parvovirus B19 infections occurred in 823 living and 1225 deceased donor kidney transplantations from January 2016 to December 2020. The serum viral load of living donors and their corresponding recipients was evaluated before and after transplantation. Meanwhile, for the deceased donor kidney transplantation, the serum viral load of recipients was only tested after transplantation; If recipients of deceased donor subsequently developed B19V infection, the serum viral load of recipients and their corresponding donors before transplantation would then be further traced. 
Results: 15 living donors were human parvovirus B19V DNAemia positive before the donation, of which B19V DNAemia occurred in 3 corresponding recipients. In deceased donor kidney transplantation, DNAemia occurred simultaneously in 18 recipients and their corresponding 9 donors. 1 living donor recipient and 11 deceased donor recipients showed a progressive decline in hemoglobin and reticulocytopenia, which were all well controlled by treatment eventually. 
Conclusion: The incidence of donor-derived human parvovirus B19 infection was 0.4% and 1.5% in living and deceased kidney transplantations, respectively. Human Parvovirus B19 was seemingly unnecessary to be routinely screened for the donor. Moreover, kidneys of the donors with human parvovirus B19 infection were acceptable.