AUTHOR=Tuli Hardeep Singh , Sak Katrin , Aggarwal Poonam , Iqubal Ashif , Upadhaya Sushil K. , Kaur Jagjit , Kaur Ginpreet , Aggarwal Diwakar 

TITLE=Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.763687

DOI=10.3389/fcimb.2021.763687

ISSN=2235-2988

ABSTRACT=Within almost two last years, the world has been shaken by Covid-19 pandemic that has affected the life of all people over the world. With nearly 4.92 million deaths by 19th of October 2021 and serious health damages in millions of people, Covid-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus SARS-CoV-2 is thoroughly compiled, highlighting the changes that the virus has undergone during the last two years and discussing the approaches that medical community has undertaken in the fight against virus-induced damages.