AUTHOR=Gil-Manso Sergio , Alonso Roberto , Catalán Pilar , Sánchez-Arcilla Ignacio , Marzola Marco , Correa-Rocha Rafael , Pion Marjorie , Muñoz Patricia ,  Gregorio Marañón Microbiology-ID COVID-19 Study Group , Alcalá Luis , Aldámiz Teresa , Alonso Roberto , Álvarez Beatriz , Álvarez-Uría Ana , Arias Alexi , Bermúdez Elena , Bouza Emilio , do-Serrano Sergio Buenesta , Burillo Almudena , Carrillo Raquel , Catalán Pilar , Cercenado Emilia , Cobos Alejandro , Díez Cristina , Escribano Pilar , Estévez Agustín , Fanciulli Chiara , Galar Alicia , García Mª Dolores , Viedma Darío García de , Gijón Paloma , González Adolfo , Guillén Helmuth , Herranz Jesús Guinea, Marta , Irigoyen Álvaro , Haces Laura Vanessa , Kestler Martha , López Juan Carlos , Losada Carmen Narcisa , Machado Marina , Marín Mercedes , Martín-Rabadán Pablo , Molero-Salinas Andrea , Muñoz Pedro Montilla, Patricia , Olmedo María , Padilla Belén , Palomino-Cabrera Rosalía , Palomo María , Pérez-Granda María Jesús , Peñas-Utrilla Daniel , Pérez-Lago Laura , Pérez Leire , Reigadas Elena , Rincón Cristina , Rodríguez Belén , Rodríguez Sara , Rodríguez-Grande Cristina , Rojas Adriana , Ruiz-Serrano María Jesús , Sánchez Carlos , Sánchez Mar , Sanz-Pérez Amadeo , Serrano Julia , Tejerina Francisco , Valerio Maricela , Veintimilla Mª Cristina , Vesperinas Lara , Vicente Teresa , Villa Sofíade la 

TITLE=IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1035155

DOI=10.3389/fcimb.2022.1035155

ISSN=2235-2988

ABSTRACT=Since the COVID-19 outbreak, specific mRNA-based vaccines anti-SARS-CoV-2 have been developed and distributed worldwide. Because mRNA vaccines have been used for the first time against COVID-19, there are several questions regarding their capacity to confer immunity and the durability of the specific anti-SARS-CoV-2 response. Therefore, the objective of this study was to recruit a large cohort of healthcare workers of the Gregorio Marañón Hospital vaccinated with mRNA-1273 or BNT126b2 vaccines and to follow up the IgG Anti-S levels for 8 months post-vaccination. We recruited 4,970 volunteers and measured IgG Anti-S antibodies on days 30 and 240 post-vaccination. We observed that both vaccines induced high levels on day 30, and drastic wane was observed on day 240, with mRNA-1273 being the vaccine that induced higher levels compared to BNT162b2. Stratifying by vaccine type, age, and gender, we identified that older mRNA-1273 vaccinated volunteers had higher antibody levels compared to younger ones, contrary to what is happening in BNT162b2 volunteers. In conclusion, we observed that mRNA-1273 has a higher capacity to induce a humoral response than BNT162b2, and that, at least, age is a factor implicated in the specific response.