AUTHOR=Fordjour Fatima Amponsah , Kwarteng Alexander 

TITLE=The filarial and the antibiotics: Single or combination therapy using antibiotics for filariasis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1044412

DOI=10.3389/fcimb.2022.1044412

ISSN=2235-2988

ABSTRACT=Filarial infections caused by nematodes mainly include lymphatic filariasis (LF) and onchocerciasis (Oncho), causing severe morbidities such as elephantiasis, skin diseases and blindness. Although there is significant decrease in microfilariae (mf) prevalence following mass drug administration (IVM/DEC/ALB administration), this is temporal, in that there is reported microfilaria repopulation 6-12 months after treatment. Wolbachia bacteria have been recommended as a novel target presenting antibiotic-based treatment for filarial disease. Potency of antibiotics against filarial diseases is undoubtful, however, the duration for treatment remains a hurdle yet to be overcome in filarial disease treatment.