AUTHOR=Chen Yuanxin , Huang Zhijie , Tang Zhengming , Huang Yisheng , Huang Mingshu , Liu Hongyu , Ziebolz Dirk , Schmalz Gerhard , Jia Bo , Zhao Jianjiang 

TITLE=More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.815318

DOI=10.3389/fcimb.2022.815318

ISSN=2235-2988

ABSTRACT=Fusobacterium nucleatum is a common oral opportunistic bacterium, which can cause a variety of infections. In recent years, studies have shown that Fusobacterium nucleatum is enriched in the related lesions of periodontal disease, halitosis, dental pulp infection, oral cancer and systemic diseases. Thereby, it can promote the initiation and/or progression of these conditions. This article reviews the research progress on Fusobacterium nucleatum in oral and systemic diseases, including epidemiological evidence, possible pathogenic mechanisms and treatment methods. New viewpoints resulting from recent studies can help to understand the role of Fusobacterium nucleatum in the host and provide a basis for finding new methods for diagnosis and treatment of Fusobacterium nucleatum-related diseases.