AUTHOR=Sayardoust Shariel , Johansson Anders , Jönsson Daniel 

TITLE=Do Probiotics Cause a Shift in the Microbiota of Dental Implants—A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.823985

DOI=10.3389/fcimb.2022.823985

ISSN=2235-2988

ABSTRACT=Objective
The primary aim of the current systematic review and meta-analysis was to evaluate the potential microbiological effect of probiotics on the implant microbiota. The secondary aim was to evaluate if probiotics has any effect as an adjunct to non-surgical peri-implant treatment, in reducing peri-implant mucositis and peri-implantitis clinical parameters, bleeding on probing (BoP), modified Gingival Index (mGI) and pocket depth.
Methods
Research focus questions were constructed in accordance with the Participants, Intervention, Comparison and Outcomes (PICO) criteria and a PROSPERO protocol was registered. A comprehensive systematic search in MEDLINE via the PubMed, Scopus and Web of Science Core Collection databases was conducted. Two independent reviewers screened the reports based on the PICO criteria, inclusion and exclusion criteria. 
Results
467 records were identified, ultimately 7 papers were included. 6 papers in the qualitative synthesis of microbiological effect and 4 in a meta-analysis synthesis on pocket depth. The data synthesis showed that probiotics had no detectable effect on the implant microflora and following data synthesis no clinical peri-implantitis variable showed a significantly beneficial effect from probiotics in the test group compared to the control group. 
Conclusion
Within the limitations of this review the oral implant microflora is not affected by probiotics, nor does probiotics add any effect to conventional non-surgical treatment of peri-implant mucositis and peri-implantitis.