AUTHOR=Yang Feixiang , Zhang Ning , Chen Yuxin , Yin Jiancai , Xu Muchen , Cheng Xiang , Ma Ruyi , Meng Jialin , Du Yinan 

TITLE=Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.873304

DOI=10.3389/fcimb.2022.873304

ISSN=2235-2988

ABSTRACT=Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouse disease (HFMD). Studies report that EV71-induced infections including aseptic meningitis, acute flaccid paralysis and even neurogenic pulmonary edema, can progress to severe neurological complica-tions in infants, young children, and the immunosuppressed population. The mechanism of neurological diseases caused by EV71 has not been fully explored. Non-coding RNA (ncRNA) refers to RNA that does not encode proteins. Previous findings indicate that ncRNAs play a key role in biological processes and disease development associated with EV71. This review summa-rized recent advances concerning the impacts of ncRNAs on neurological diseases caused by in-teraction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, treatment and diagnosis of EV71-induced neurological complications.