AUTHOR=Rodriguez G. Marcela , Sharma Nishant , Biswas Ashis , Sharma Nevadita TITLE=The Iron Response of Mycobacterium tuberculosis and Its Implications for Tuberculosis Pathogenesis and Novel Therapeutics JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=Volume 12 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.876667 DOI=10.3389/fcimb.2022.876667 ISSN=2235-2988 ABSTRACT=Abstract Most pathogenic bacteria require iron for growth. But due to its poor solubility and propensity to catalyze the generation of reactive oxygen species (ROS), iron is not freely available in the mammalian host. Access to iron in the host is an important factor in the outcome of bacterial infections; iron limitation frequently induces virulence and drives pathogenic interactions with host cells. Here, we review the response of Mycobacterium tuberculosis to changes in iron availability, the relevance of this response to TB pathogenesis, and its potential for the design of new therapeutic interventions.