AUTHOR=Sun Boyuan , He Xin , Zhang Wen 

TITLE=Findings on the Relationship Between Intestinal Microbiome and Vasculitis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.908352

DOI=10.3389/fcimb.2022.908352

ISSN=2235-2988

ABSTRACT=Microbiome descriptions are now available in patients with small, medium, large, and variable vessel vasculitis. Dysbiosis can be found frequently in vasculitis patients with reduced microbial diversity and abundance, compared with other diseases or healthy controls. Dominant bacteria discovered in different studies vary greatly, but in general, the intestinal microbiome of vasculitis patients tends to contain more pathogenic and less beneficial bacteria. Improvement or resolution of dysbiosis has been observed after treatment in a few longitudinal studies. In addition, some molecular changes relating to intestinal permeability and immune response have been found in animal models of vasculitis diseases.