AUTHOR=Chen Yunqing , Xu Yan , Zhang Kan , Shen Liang , Deng Min 

TITLE=Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.922511

DOI=10.3389/fcimb.2022.922511

ISSN=2235-2988

ABSTRACT=The outbreak of COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has spread worldwide and caused dramatic threaten of global public health. SARS-CoV-2 infection not only influence the respiratory system, but also lead to hepatic injury. Ferroptosis is a distinct iron-dependent form of non-apoptotic cell death, which has been investigated in various pathological conditions, such as cancer, ischemia/reperfusion injury as well as liver diseases. To date, whether ferroptosis take part in the pathophysiological process of COVID-19-related liver injury has not been elaborated. This review describes the pathological changes in COVID-19-related liver injury and speculates ferroptosis as a potential mechanism in COVID-19-related hepatic injury. Furthermore, we discuss ferroptosis might be a therapeutic target for COVID-19-related liver injury. Discoveries in these areas will improve our understanding for strategies to prevent and treat hepatic injury caused by COVID-19.