AUTHOR=He Jia-Qi , Chen Qin , Wu Sheng-Jun , Wang De-Qin , Zhang Shen-Yingjie , Zhang Song-Zhao , Chen Rui-Lin , Wang Jia-Feng , Wang Zhen , Yu Chen-Huan 

TITLE=Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.937864

DOI=10.3389/fcimb.2022.937864

ISSN=2235-2988

ABSTRACT=Chronic obstructive pulmonary disease (COPD) has been recently considered as a common risk factor for non-small cell lung cancer (NSCLC). However, very few studies have been conducted on the effects of COPD on lung microbiota in NSCLC patients. To identify the lung microbiota of the patients with COPD combined NSCLC (CN), the microbiome in the induced sputa of 172 patients was analyzed by 16s rDNA sequencing. The results displayed that there were not significant differences in the bacterial diversities of induced sputa among the patients with COPD, NSCLC, and CN, and did not exhibit intrinsic differences among the patients with different pathological types of lung cancer. After surgical operation, the diversities of induced sputa in CN patients were significantly decreased. More remarkably, both the microbial community phenotypes and components in induced sputa of CN patients obviously differed from those in COPD or NSCLC patients. Compared with those in patients with COPD and NSCLC alone, the relative abundances of Streptococcus, Veillonella, Moraxella and Actinomyces in CN patients were significantly reduced, but Neisseria and Acinetobacter were significantly elevated, resulting in the increase of gram-negative microbiota, potentially pathogenicity and stress tolerant of microbiota as well as the enhancement of microbial glycolipid metabolism, amino acid metabolism and oxidant stress. Although COPD could not affect the number of pulmonary flora species in NSCLC patients, these significant alterations in the microbial populations, phenotypes, and functions of induced sputa induced by COPD would contribute to the inflammation-derived cancer progression in CN patients.