AUTHOR=Tan Jiaxing , Chen Ming , Wang Yutong , Tang Yi , Qin Wei 

TITLE=Emerging trends and focus for the link between the gastrointestinal microbiome and kidney disease

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.946138

DOI=10.3389/fcimb.2022.946138

ISSN=2235-2988

ABSTRACT=The clinical value of the relationship between gastrointestinal microbiome imbalance and its corresponding interventions with kidney disease is emerging. This study describes the hotspots and evolution of gastrointestinal microbiome and kidney disease research over the past three decades by scientific collaboration networks and finally predicts future trends in the field through bibliometric analysis and visualization studies. CiteSpace was used to explore the original articles from January 1990 to August 2021 in the Scopus database using the terms “gastrointestinal microbiome” and “kidney disease” (and their synonyms in MeSH). Co-country, co-institute, co-authorship and journals are analysed, and the emergent trend in this field is presented through co-occurring keywords and co-citation analysis. The number of studies combining gastrointestinal microbiomes with kidney diseases has increased significantly over the past two decades. The United States is the leading country in the number of documents, and the leading institution is the Cleveland Clinic. The most landmark articles in the field are on chronic renal failure, l carnitin, and cardiovascular disease. The pathogenesis of uremia toxin is an emerging trend in gastrointestinal microbiomes and kidney diseases. In addition, probiotic or synbiotic supplements have strong clinical value in adjusting abnormal intestinal symbiotic environments. This study demonstrates a growing understanding of the interaction between gut microbiota and kidney disease over time. Using microbial supplements to improve the living conditions of kidney disease patients is a promising and hot research focus.