AUTHOR=Liu Ning , Yang Gengxia , Dang Yan , Liu Xin , Chen Ming , Dai Fangfang , Ding Xiurong , Li Wenlei , Li Guangming , Lou Jinli , Chen Dexi , Yu Yanhua 

TITLE=Epidemic, risk factors of carbapenem-resistant Klebsiella pneumoniae infection and its effect on the early prognosis of liver transplantation

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.976408

DOI=10.3389/fcimb.2022.976408

ISSN=2235-2988

ABSTRACT=Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection remains a major cause of morbidity and mortality in early-stage post-liver transplantation (LT). 
Methods: We retrospectively analyzed the demographic, clinical, infection characteristics, and the 3-months post-LT prognosis of all patients who received LT in our hospital between January 2019 and December 2021. 
Results: Among the 272 LT recipients, sixty-two cases (22.8%) had at least one infection within 3-months post-LT. Twenty-eight recipients were dead with bacteria infection. Twelve recipients were dead with CRKP infection. The risk factors independently related to 3-months mortality were age (Odds ratio (OR)= 1.126, 95% Confidence interval (CI): 1.009~1.257; P=0.034), mechanical ventilation (MV) (OR=1.206, 95% CI: 1.039~1.401; P =0.014), and CRKP infection (OR=18.240, 95% CI: 2.206~150.842; P =0.007). In CRKP infection, the length of ICU stay (OR=1.067, 95% CI: 1.015~1.122; P=0.011), pre-operation infection (POI) (OR=6.733, 95% CI: 1.160~39.088; P=0.034), and hepatocellular carcinoma (HCC) (OR=26.772, 95% CI: 1.747~410.187; P=0.018) were the independent risk factors. With COX multivariate regression analysis, the 3-months survival rate of CRKP infected recipients was significantly lower than that without CRKP infection post-LT.
Conclusions: CRKP infection is closely correlated with poor prognosis in 3-months post-LT.