AUTHOR=Fang Lixin , Zhou Huoxiang , Cheng Long , Wang Yiyi , Liu Fei , Wang Suping 

TITLE=The application of mesoporous silica nanoparticles as a drug delivery vehicle in oral disease treatment

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1124411

DOI=10.3389/fcimb.2023.1124411

ISSN=2235-2988

ABSTRACT=Mesoporous silica nanoparticles (MSNs) hold the promise as safer and more effective medication delivery vehicles for treating oral disorders (Figure 1. A). As the drug's delivery system, MSNs adapt to effectively combine with a variety of medications to get over systemic toxicity and low solubility issues (Figure 1. B). MSNs, which operate as a common nanoplatform for the co-delivery of several compounds, increase therapy effectiveness and show promise in the fight against antibiotic resistance. MSNs offer a non-invasive and biocompatible platform for delivery that produces long-acting release by responding to minute stimuli in the cellular environment (Figure 1. C). MSN-based drug delivery systems for the treatment of periodontitis, cancer, dentin hypersensitivity, and dental cavities have recently been developed as a result of recent, unparalleled advancements. The applications of MSNs to be embellished by oral therapeutic agents in stomatology are discussed in this paper.