AUTHOR=Zou Qian , Feng Lijuan , Cai Xunchao , Qian Yun , Xu Long 

TITLE=Esophageal microflora in esophageal diseases

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1145791

DOI=10.3389/fcimb.2023.1145791

ISSN=2235-2988

ABSTRACT=With the development of endoscopic technology, more and more patients with esophageal disease have been found, while the pathogenesis of many esophageal diseases remains unclear. In recent years, a large number of studies on intestinal flora have shown that the occurrence and development of many intestinal diseases were related to intestinal flora, so, many researchers focused their attention on esophageal flora to explore the pathogenesis and early diagnosis and treatment of esophageal diseases. This paper reviewed the normal esophageal flora and the changes of esophageal flora under different esophageal disease states. It was found that there are differences in esophageal microflora among Gastroesophageal Reflux, Barrett's esophagus, eosinophilic esophagitis and normal esophagus. The normal esophageal flora was dominated by gram-positive bacteria, especially Streptococcus, while the esophageal flora under esophagitis was dominated by gram-negative bacteria. Meanwhile, the diversity of esophageal flora in patients with esophageal cancer decreased significantly. Studies have found some potential microbial biomarkers of esophageal cancer and Fusobacterium nucleatum was thought closely related to ESCC pT stage and clinical stage.