AUTHOR=Tsigalou Christina , Paraschaki Afroditi , Bragazzi Nicola Luigi , Aftzoglou K. , Stavropoulou Elisavet , Tsakris Z. , Vradelis S. , Bezirtzoglou Eugenia 

TITLE=Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1191126

DOI=10.3389/fcimb.2023.1191126

ISSN=2235-2988

ABSTRACT=Intestinal microorganisms play a crucial role in shaping the host immunity and maintaining homeostasis. A principal function of these microbes is also to offer protection against pathogen colonization. Nevertheless, alterations in gut bacterial composition may occur and these alterations have been linked with the pathogenesis of several diseases. In surgical practice, studies revealed that the microbiome of patients undergoing surgery changes and several post-operative complications seem to be associated with the gut microbiota composition. In this review, we aim to provide an overview of Gut Microbiome in surgical disease. We refer to several studies which describe alterations of GM in patients undergoing different types of surgery, we focus on the impacts of peri-operative interventions on GM and the role of GM in development of post-operative complications, such as anastomotic leak.