AUTHOR=Pang Feng , Long Qinqin , Wei Min 

TITLE=Immune evasion strategies of bovine viral diarrhea virus

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1282526

DOI=10.3389/fcimb.2023.1282526

ISSN=2235-2988

ABSTRACT=Bovine viral diarrhea virus (BVDV) is a significant pathogen that causes great economic losses in the global livestock industry. During the long-term interactions between BVDV and its hosts, the virus has evolved multiple strategies to evade the host's innate immunity and adaptive immunity, promoting viral survival and replication. This review focuses on the most recent research on immune evasion strategies employed by BVDV, including evading type I IFN signaling pathway, evading host adaptive immunity, mediating NF-κB signaling pathway, mediating cell apoptosis and inducing autophagy. Unraveling the immune evasion mechanisms by BVDV will improve our understanding of BVDV′s pathogenesis and help to develop more effective therapies to prevent, control and eliminate BVDV.