AUTHOR=Wang Kun , Zhang Jingjing , Zhang Yihao , Xue Junze , Wang He , Tan Xiaojie , Jiao Xuelong , Jiang Haitao 

TITLE=The recovery of intestinal barrier function and changes in oral microbiota after radiation therapy injury

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1288666

DOI=10.3389/fcimb.2023.1288666

ISSN=2235-2988

ABSTRACT=Colorectal cancer (CRC), the third most prevalent malignant tumor, frequently necessitates neoadjuvant chemo-radiotherapy for advanced stages. Radiotherapy can impair the intestinal mucosal barrier, potentially leading to perioperative complications. The intestinal microbiota, a key component of this barrier, shows alterations in CRC patients, as evidenced by changes in oral microbiota. This study aims to evaluate immunoglobulin SIgA levels, inflammatory markers, and lymphocyte subset counts and ratios in intestinal mucosal samples at various intervals post-radiotherapy. The goal is to determine the optimal timing for surgery following radiotherapy and to identify potential probiotics or immunomodulators through high-throughput sequencing of bacterial 16s rRNA in saliva microbiota. This approach could offer novel strategies to mitigate perioperative complications stemming from radiotherapy-induced intestinal damage.