AUTHOR=Gu Zhixia , Zhang Yuanyuan , Zhao Xue , Liu Tingting , Sheng Shugui , Song Rui , Jin Ronghua 

TITLE=Comparing sputum microbiota characteristics between severe and critically ill influenza patients

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1297946

DOI=10.3389/fcimb.2023.1297946

ISSN=2235-2988

ABSTRACT=Reducing the incidence and mortality rate of severe and critically ill influenza has always been a focus of attention for physicians. However, few studies have compared and analyzed the respiratory microbiota of severe and critically ill influenza patients to seek potential diagnostic biomarkers. Our primary objective is to analyze the diversity and composition of sputum microbiota in severe and critically ill influenza patients. This study enrolled a total of 64 patients, with 48 falling into the severe group and 16 into the critically ill group. Alloprevotella exhibited a negative correlation with influenza Ct values, while C-reactive protein (CRP) demonstrated a positive correlation with Haemophilus and Porphyromonas. These findings offer crucial insights that lay the ground work for further investigations into the intricate relationship between lower respiratory tract (LRT) microbiota and respiratory diseases.