AUTHOR=Wang Qianfei , Gao Tianci , Zhang Weichao , Liu Dong , Li Xin , Chen Fenqiao , Mei Jianqiang 

TITLE=Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1279218

DOI=10.3389/fcimb.2024.1279218

ISSN=2235-2988

ABSTRACT=Background: The changes in gut microbiota are closely related to insomnia, but the causal relationship between them is not yet clear. Objective: To clarify the relationship between gut microbiota and insomnia, and provide genetic evidence for them, we conducted a two sample Mendelian randomization study. Methods: We used mendelian randomized two-way validation method to discuss the causal relationship. First, we downloaded 462,341 participants data of insomnia, and 18,340 participants data of gut microbiota from genome-wide association study (GWAS). Then, we used two regression models, inverse-variance weighted (IVW) and MR-Egger regression, to evaluate the relationship between exposure factors and outcomes. Finally, we took a reverse MR analysis to assess the possibility of reverse causality.The combined results show that 19 gut microbiota suggest a causal relationship with insomnia (odds ratio (