AUTHOR=Lin Yiwei , Li Xushuo , Shan Haojie , Gao Jie , Yang Yanying , Jiang Linlan , Sun Lu , Chen Yuwen , Liu Fangming , Yu Xiaowei 

TITLE=Scd-1 deficiency promotes the differentiation of CD8+ T effector

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1325390

DOI=10.3389/fcimb.2024.1325390

ISSN=2235-2988

ABSTRACT=The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. In this study, we showed that the enzyme stearoyl-CoA desaturase-1 (Scd-1) and its resulting compound, oleic acid (OA), have a substantial impact on the transformation of CD8 + naïve T cells into effector T cells.Inactivation of Scd-1 triggers the specialization of CD8 + T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. In the LCMV infection model, Scd-1 deficiency enhances resistance to viral infection. In animal models of endotoxemia, OA alleviated symptoms, reduced inflammation, and affected the differentiation and effector function of CD8 + T cells.