AUTHOR=Zhang Hongyan , Ma Li , Peng Wenbo , Wang Bing , Sun Yongning 

TITLE=Association between gut microbiota and onset of type 2 diabetes mellitus: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1327032

DOI=10.3389/fcimb.2024.1327032

ISSN=2235-2988

ABSTRACT=Aim: Mendelian randomization (MR) analysis has been used in the exploration of the role of gut microbiota (GM) in type 2 diabetes mellitus (T2DM), and however, was limited to the genus level. Herein, this study aims to investigate the relationship of GM, especially at the species level, with T2DM, in order to provide some evidence for further exploration of more specific GM taxa and pathway abundance in T2DM.This two-sample MR study was based on the summary statistics of GM from the available genome-wide association study (GWAS) meta-analysis conducted by the MiBioGen consortium as well as the Dutch Microbiome Project (DMP), whereas the summary statistics of T2DM were obtained from the FinnGen consortium released data.Inverse variance weighted (IVW), MR-Egger, strength test (F), and weighted median methods were used to examine the causal association between GM and the onset of T2DM. Cochran's Q statistics were employed to quantify the heterogeneity of instrumental variables (IVs). Bonferroni's correction was conducted to correct the bias of multiple testing. We also performed the reverse causality analysis.The corrected IVW estimates suggested increased relative abundance of family Oxalobacteraceae (OR=1.0704) and genus Oxalobacter (OR=1.0874) were associated with higher odds of T2DM, while that of species faecis (OR=0.9460) had a negative relationship with T2DM. Also, the relationships of class Betaproteobacteria, family Lactobacillaceae, species finegoldii, and species longum with T2DM were significant according to the IVW results (all P<0.05).Conclusions: GM had a potential causal association with T2DM, especially species Association between GM and occurrence of T2DM 4 faecis, finegoldii, and longum. Further studies are still needed to clarify the certain results that contradictory with previous findings.