AUTHOR=Luo Wei , Wang Lixia , Chen Zhengrong , Liu Ming , Zhao Yixue , Wu Yucan 

TITLE=Pathoimmunological analyses of fatal E11 infection in premature infants

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1391824

DOI=10.3389/fcimb.2024.1391824

ISSN=2235-2988

ABSTRACT=E11 causes acute fulminant hepatitis in newborns. We investigated the pathological changes of different tissues from premature male twins who died due to E11 infection. The E11 expression level was higher in the liver than in other tissues. IP10 was upregulated in liver tissue in the patient group, and might be regulated by IFNAR and IRF7, whereas IFNα was regulated by IFNAR or IRF5.