AUTHOR=Qin Yaqiong , Zhou Gengxu , Jiao Fengyuan , Cheng Chuan , Meng Chi , Wang Lingjie , Wu Shengping , Fan Cailiang , Li Jixiang 

TITLE=Brucella mediates autophagy, inflammation, and apoptosis to escape host killing

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1408407

DOI=10.3389/fcimb.2024.1408407

ISSN=2235-2988

ABSTRACT=Brucellosis is a serious zoonosis caused by Brucella spp. infection, which not only seriously jeopardizes the health of humans and mammals, but also causes huge economic losses to the livestock industry. Brucella is a Gram-negative intracellular bacterium that relies primarily on its virulence factors and a variety of evolved survival strategies to replicate and proliferate within cells. Currently, the mechanisms of autophagy, inflammation, and apoptosis in Brucella-infected hosts are not fully understood and require further research and discussion. This review focuses on the relationship between Brucella and autophagy, inflammation, and apoptosis to provide the scientific basis for revealing the pathogenesis of Brucella.