AUTHOR=Karunarathna Samantha C. , Patabendige Nimesha M. , Luangharn Thatsanee , Hapuarachchi Kalani K. TITLE=Ganodermataceae—current status, research, and development in Lower Mekong Basin JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=Volume 15 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1545135 DOI=10.3389/fcimb.2025.1545135 ISSN=2235-2988 ABSTRACT=The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medicine for its therapeutic properties. Species within this family, particularly Ganoderma lucidum, have been valued for centuries in regions such as China, Korea, and Japan for enhancing vitality, longevity, and overall health. However, the taxonomy of Ganodermataceae remains complex, with ongoing debates about species identification and classification. Members of this family are globally distributed, with the Lower Mekong Basin—comprising Laos, Thailand, Cambodia, and Vietnam—offering optimal conditions for their growth due to its warm, humid climate. In the Lower Mekong Basin, the species of Ganodermataceae are significant for their medicinal applications in treating conditions such as bronchitis, hepatitis, diabetes, and cancer. They also hold significant economic value, being used in products like teas, dietary supplements, and cosmetics. Ganoderma lucidum is particularly notable as a high-value market product in this region. Recent research has revealed a rich diversity of Ganodermataceae species in the region, highlighting their ecological roles, medicinal properties, and importance in plant pathology, particularly in addressing diseases in crops such as oil palm. These findings underscore the need for further research into the taxonomy, ecological functions, and potential applications of Ganodermataceae species. Advancing our understanding will support sustainable utilization, conservation efforts, and the maximization of their medicinal and commercial benefits.