AUTHOR=Liu Xudong , Yao Yuteng , Xiao Aoyi , Cao Dingyan , Zhang Jingheng , Shi Yanan , Zhong Qing , He Zilong , Wu Wenming 

TITLE=Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1549319

DOI=10.3389/fcimb.2025.1549319

ISSN=2235-2988

ABSTRACT=Despite numerous studies investigating intratumoral microorganisms and their significant roles in cancer initiation, progression, and treatment efficacy, a systematic understanding of intratumoral microorganisms remains lacking. Herein, we conducted a study using 16S rDNA data on seven types of cancer, comprising a total of 783 samples. It’s worth noting that Pseudomonas, Streptococcus, and Prevotella were found to be shared with the microbial communities of the seven cancers, suggesting that these may be associated with the occurrence and development of cancers. We anticipate establishing a foundation for related research and exploring potential methods for cancer treatment.