AUTHOR=Li Yanjian , Qiao Yue , Ma Yuanyuan , Xue Peng , Ding Chen 

TITLE=AI in fungal drug development: opportunities, challenges, and future outlook

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1610743

DOI=10.3389/fcimb.2025.1610743

ISSN=2235-2988

ABSTRACT=The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance. This review evaluates the current landscape of fungal infections, highlights the limitations of existing antifungal therapies, and examines the transformative potential of AI in drug discovery and development. We specifically focus on how AI can enhance the identification of new antifungal agents and improve therapeutic strategies. Despite numerous opportunities for advancement, significant challenges remain, particularly regarding data quality, regulatory frameworks, and the complexities associated with the drug development process. This review aims to provide insights into recent advancements in AI technologies, their implications for the future of fungal drug development, and the necessary research directions to effectively leverage AI for improved patient outcomes.