AUTHOR=Maggio Nicola , Blatt Ilan , Vlachos Andreas , Tanne David , Chapman Joab , Segal Menahem TITLE=Treating seizures and epilepsy with anticoagulants? JOURNAL=Frontiers in Cellular Neuroscience VOLUME=Volume 7 - 2013 YEAR=2013 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2013.00019 DOI=10.3389/fncel.2013.00019 ISSN=1662-5102 ABSTRACT=

Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system. Binding of thrombin to protease-activated receptors (PARs) in the brain appears to have multiple actions affecting both health and disease. Specifically, thrombin has been shown to lead to the onset of seizures via PAR-1 activation. In this perspective article, we review the putative mechanisms by which thrombin causes seizures and epilepsy. We propose a potential role of PAR-1 antagonists and novel thrombin inhibitors as new, possible antiepileptic drugs.