AUTHOR=Kayakabe Mikiko , Kakizaki Toshikazu , Kaneko Ryosuke , Sasaki Atsushi , Nakazato Yoichi , Shibasaki Koji , Ishizaki Yasuki , Saito Hiromitsu , Suzuki Noboru , Yanagawa Yuchio TITLE=Motor dysfunction in cerebellar Purkinje cell-specific vesicular GABA transporter knockout mice JOURNAL=Frontiers in Cellular Neuroscience VOLUME=Volume 7 - 2013 YEAR=2014 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2013.00286 DOI=10.3389/fncel.2013.00286 ISSN=1662-5102 ABSTRACT=
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the adult mammalian central nervous system and plays modulatory roles in neural development. The vesicular GABA transporter (VGAT) is an essential molecule for GABAergic neurotransmission due to its role in vesicular GABA release. Cerebellar Purkinje cells (PCs) are GABAergic projection neurons that are indispensable for cerebellar function. To elucidate the significance of VGAT in cerebellar PCs, we generated and characterized PC-specific VGAT knockout (L7-VGAT) mice.