AUTHOR=Franchi Sira A. , Astro Veronica , Macco Romina , Tonoli Diletta , Barnier Jean-Vianney , Botta Martina , de Curtis Ivan TITLE=Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons JOURNAL=Frontiers in Cellular Neuroscience VOLUME=Volume 10 - 2016 YEAR=2016 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2016.00289 DOI=10.3389/fncel.2016.00289 ISSN=1662-5102 ABSTRACT=
Interneurons are essential modulators of brain activity and their abnormal maturation may lead to neural and intellectual disabilities. Here we show that cultures derived from murine medial ganglionic eminences (MGEs) produce virtually pure, polarized γ-aminobutyric acid (GABA)-ergic interneurons that can form morphologically identifiable inhibitory synapses. We show that Rac GTPases and a protein complex including the GIT family scaffold proteins are expressed during maturation