AUTHOR=Jia Jia , Cheng Jian , Wang Cheng , Zhen Xuechu 

TITLE=Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 12 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00314

DOI=10.3389/fncel.2018.00314

ISSN=1662-5102

ABSTRACT=A large body of evidences indicates that sigma-1 receptor is an important drug target for a number of neuropsychiatric disorders. Sigma-1 receptor is enriched in central nervous system. In addition to neurons, both cerebral microglia and astrocytes express sigma-1 receptor. Activation of sigma-1 receptor is known to elicit potent neuroprotective effect and promote neuronal survival via multiple mechanisms, including promoting mitochondrial functions, defending oxidative stress and regulating neuroimmnological functions. In this review, we focus on the emerging importance of sigma-1 receptors in regulating neuroinflammation and discuss the recent advances on the receptor-modulating neuroinflammation in the pathophysiology and therapy of neurodegenerative disorders.