AUTHOR=Rahimi-Balaei Maryam , Bergen Hugo , Kong Jiming , Marzban Hassan 

TITLE=Neuronal Migration During Development of the Cerebellum

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 12 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00484

DOI=10.3389/fncel.2018.00484

ISSN=1662-5102

ABSTRACT=Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in neuronal migration may result in a neurological disorder. The cerebellum, as a part of the CNS, plays a pivotal role in motor coordination and also non-motor functions such as emotion, cognition and language. The excitatory and inhibitory neurons within the cerebellum originate from different distinct germinal zones and migrate through complex routes to assemble in a well-defined neuronal organization in the cerebellar cortex and nuclei. In this review, we consider the neuronal migration modes and pathways from germinal zones to the final position in cerebellar cortex and nuclei.  We also review the cellular and molecular mechanisms involved in cerebellar neuronal migration. Finally, we describe some diseases and animal models associated with defects in neuronal migration.