AUTHOR=Han Yu , Yuan Mei , Guo Yi-Sha , Shen Xin-Ya , Gao Zhen-Kun , Bi Xia 

TITLE=Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.704334

DOI=10.3389/fncel.2021.704334

ISSN=1662-5102

ABSTRACT=Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca2+ homeostasis. The proportion of ischemic stroke in central nervous system diseases is increasing with each passing year, which is a prevalent reason of death and disability in the world. Cerebral ischemia causes several stress responses where ER in stress state initiates unfolded protein response (UPR) due to accumulation of misfolded and unfolded protein as well as Ca2 + overload, which is associated with a specialized set of inflammatory and apoptotic signaling pathways controlling the fate of nerve cells. Mild ER stress promotes cells to break away from danger signals and enter the adaptive procedure with the activation of pro-survival mechanism to rescue ischemic injury, while chronic ER stress generally serves as a detrimental role on nerve cells via triggering diverse pro-apoptotic mechanism. A reasonable understanding and exploration of the underlying molecular mechanism related to ER stress and cerebral ischema is a prerequisite for a major breakthrough in stroke treatment in the future. This review focuses on recent findings of the ER stress as well as the progress research of mechanism in ischemic stroke prognosis provide a new treatment idea for recovery of cerebral ischemia.